Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive
properties. A gene in the lipocalin cluster encodes alpha-1-microglobulin
together with a Kunitz-type proteinase inhibitor, bikunin. The gene is
translated into the alpha-1-microglobulin-bikunin precursor, which is
subsequently cleaved and the two proteins secreted to the blood
separately. Alpha-1-microglobulin is found in blood and in connective
tissue in most organs. It is most abundant at interfaces between the
cells of the body and the environment, such as in lungs, intestine,
kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory
protein with a broad spectrum of possible clinical applications and
seems a promising marker for evaluation of tubular function.
Quantity: 100 ug
Immunogen: Human and rat
alpha-1-microglobulin Alpha-1-microglobulin (alpha1m) is a plasma
glycoprotein, synthesized by the liver. It has immunosuppressive
properties and binds to the surface of most blood cells. Alpha1m has a
low molecular weight and is filtrated through the kidneys to the urine.
Its concentration in urine is elevated as a result of renal tubular
disorders and the urine alpha1m concentration is used in clinical
medicine to diagnose renal tubular failure.
Type of antibody: Monoclonal
mouse IgG2a, purified by gel filtration
Antibody format: lyophilized
Tested applications: Western
Blot and ELISA(working concentration: 0.2-2 mg/L),
immunoprecipitation, radioimmunoassay, immunohistochemistry, affinity
References: Babiker-Mohamed H.,
Forsberg M., Olsson M.L., Winquist O., Nilson B.H.K., Lögdberg L. and
Åkerström B. (1991) Characterization of monoclonal anti-alpha-1-microglobulin
antibodies: Binding strength, binding sites, and inhibition of alpha-1-microglobulin-induced
lymphocyte stimulation. Scand. J. Immunol. 34:655-666.
ALL ANTIBODIES ARE FOR RESEARCH