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Product sheet »

 

Product description

 

Background
Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

Quantity:  100 ug

Immunogen: Human and rat alpha-1-microglobulin Alpha-1-microglobulin (alpha1m) is a plasma glycoprotein, synthesized by the liver. It has immunosuppressive properties and binds to the surface of most blood cells. Alpha1m has a low molecular weight and is filtrated through the kidneys to the urine. Its concentration in urine is elevated as a result of renal tubular disorders and the urine alpha1m concentration is used in clinical medicine to diagnose renal tubular failure.

Type of antibody: Monoclonal mouse IgG2a, purified by gel filtration

Antibody format: lyophilized

Tested applications: Western Blot and ELISA(working concentration: 0.2-2 mg/L),
immunoprecipitation, radioimmunoassay, immunohistochemistry, affinity chromatography <br>

References: Babiker-Mohamed H., Forsberg M., Olsson M.L., Winquist O., Nilson B.H.K., Lögdberg L. and Åkerström B. (1991) Characterization of monoclonal anti-alpha-1-microglobulin antibodies: Binding strength, binding sites, and inhibition of alpha-1-microglobulin-induced lymphocyte stimulation. Scand. J. Immunol. 34:655-666.   

ALL ANTIBODIES ARE FOR RESEARCH PURPOSE ONLY

 

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Last modified: 05/29/09