Background
Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

Quantity:  200 ul
 
Immunogen: Rat alpha-1-microglobulin or protein HC

Type of antibody:  polyclonal

Antibody format: lyophilized rabbit serum

Tested applications: Western Blot (working dilution approx. 1:2000), soluble radioimmunoassay (RIA), SPRIA, immunocytochemistry
 
References:  Falkenberg C., Grubb A. and Åkerström B. (1990) Isolation of rat serum alpha-1-microglobulin. Identification of a complex with alpha-inhibitor-3. a rat alpha macroglobulin homologue. J. Biol. Chem. 265: 16150-16157.
 
ALL ANTIBODIES ARE FOR RESEARCH PURPOSE ONLY