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Product sheet »

 

Product description

 

Background
mPGES-1 is an inducible glutathione dependent prostaglandin E synthase that converts cyclooxygenase derived PGH2 into PGE2.

Quantity: 100 ul
 
Antibody format:  lyophilized rabbit serum
 
Type of antibody:  polyclonal

Immunogen: recombinant human Purified 6-His mPGES-1. Inducible glutathione dependent prostaglandin E synthase. Converts cyclooxygenase derived PGH2 into PGE2.

Cross-reactivity: reacts with rat, human and sheep mPGES-1.

Tested applications:  Western Blot - working dilution: 1:10 000; Immunohistochemistry: 1:6 000.
 
References:
Westman, M.; Korotkova, M.; af  Klint, E.; Stark, A.; Audoly, L. P.; Klareskog, L.;
Ulfgren, A.-K.; Jakobsson, P.-J. Expression of Microsomal Prostaglandin E Synthase in Rheumatoid Arthritis Synovium. 2003, Submitted for publication
Thoren, S.; Weinander, R.; Saha, S.; Jegerschold, C.; Pettersson, P. L.; Samuelsson, B.;
Hebert, H.; Hamberg, M.; Morgenstern, R.; Jakobsson, P. J. Human microsomal prostaglandin E synthase-1: purification, functional characterization and  projection structure determination J. Biol. Chem., 2003, 278, 22199
Jakobsson, P. J.; Engblom, D.; Ericsson-Dahlstrand, A.; Blomqvist, A. Microsomal prostaglandin E synthase: A key enzyme in PGE2 biosynthesis and inflammation Current Medicinal Chemistry- Anti-inflammatory & Anti-Allergy Agents, 2002, 1,167
Engblom, D.; Ek, M.; Andersson, I. M.; Saha, S.; Dahlstrom, M.; Jakobsson, P. J.; Ericsson-Dahlstrand, A.; Blomqvist, A.Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis J. Comp. Neurol., 2002, 452, 205
Stichtenoth, D. O.; Thoren, S.; Bian, H.; Peters-Golden, M.; Jakobsson, P. J.; Crofford, L. J. Microsomal prostaglandin e synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells J. Immunol., 2001, 167,469
Ek, M.; Engblom, D.; Saha, S.; Blomqvist, A.; Jakobsson, P. J.; Ericsson-Dahlstrand, A. Inflammatory response: pathway across the blood-brain barrier Nature, 2001, 410, 430
Thoren, S.; Jakobsson, P. J. Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4 Eur. J. Biochem., 2000, 267, 6428
Jakobsson, P. J.; Thoren, S.; Morgenstern, R.; Samuelsson, B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target Proc. Natl. Acad. Sci. U. S. A., 1999, 96,7220

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Last modified: 05/29/09