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Product sheet »

 

Product description

 

Background
One characteristic feature of Alzheimer’s disease is the deposition of amyloid beta-peptide (Abeta) as amyloid plaques within specific regions of the human brain. Abeta is derived from the amyloid beta-peptide precursor protein (beta-APP) by the intramembranous cleavage activity of beta -secretase. PEN-2 is a critical component of PS1/gamma secretase.

Quantity:
200 ug

Immunogen: the antibody was raised against the N-terminal eleven residues of human Pen-2. Pen-2 is the smallest component of the multi-protein γ-secretase complex. Chosen synthetic peptide has been conjugated to KLH.

Type of antibody: polyclonal

Antibody format: affinity purified rabbit IgG, lyophilized

Tested applications: Western Blot:  1-5 mg/ml

Reference: Farmery, M.R., et. al (2003) Partial purification and characterization of -secretase from post-mortem human brain. J. Biol. Chem. 278: 867-872.
Bergman, A., et al. (2004) Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-nediate degradation in the absence of presenilin. J. Biol. Chem. 279: 16744-16753.

ANTIBODIES ARE FOR RESEARCH PURPOSE ONLY

 

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Last modified: 05/29/09