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0032 (0)16 41 44 07

+32 1650 9045

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Deconjugating Enzymes, Inhibitors & Substrates

The enzymes that catalyze the removal of ubiquitin from native conjugates, ubiquitin C-terminal extension peptides, ubiquitin precursor proteins, linear poly-ubiquitin fusions or disassembly of ubiquitin chains are known as deconjugating enzymes (or deubiquitinating enzymes, DUBs).  There are also enzymes that specifically hydrolyze C-terminal isopeptide bonds for ubiquitin-like proteins: SUMO-specific proteases (SENPs), NEDD8-specific proteases (NEDP1, COP9 signalosome) and ISG15-specific proteases (UBP43).

Ubiquitin-Specific Proteins, human recombinant 
 
Deconjugating Enzymes   
Ataxin-3 (MJD protein 1)  USP2CD (UBP41 catalytic domain) 
Cat.#: E-341 (HIS-tagged) Cat.#: E-506 (HIS-tagged)
 
A20CD (TNFAIP3 catalytic domain) USP7CD (HAUSP catalytic domain) 
Cat.#: E-344 (HIS-tagged) Cat.#: E-518 (HIS-tagged)
 
Bap1  USP14
Cat.#: E-345 (HIS-tagged) Cat.#: E-544 
 
DUB3   
Cat.#: E-348 (HIS-tagged)  
 
 
Inhibitors Substrate
Ubiquitin Aldehyde  Ubiquitin AMC 
Cat.#: U-201  Cat.#: U-550 
 
Ubiquitin Vinyl Sulfone   
Cat.#: U-202   
 
 
ISG15-Specific Proteins, human recombinant 
 
Deconjugating Enzyme Substrate
UBP43 (USP18) ISG15 AMC 
Cat.#: E-600 (HIS-tagged) Cat.#: UL-553
 
 
Inhibitors  
ISG15 Aldehyde   
Cat.#: UL-602   
ISG15 Vinyl Sulfone  
Cat.#: UL-603   

 

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Last modified: 05/29/09