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about the great benefits:
SAINT-MIX for the transfection of Embryonic Stem cells
Recent SAINT-MIX Articles:
Geiger T, Plosone 2008 Feb Vol 3(2):e1574
Anomalous Features of EMT during
Keratinocyte Transformation.(Transfection was performed with
(Synvolux Therapeutics B.V.) according to the manufacturer
Shafiei F, Oncogene 2008 Vol 27,
2602-2612. DNMT3A and DNMT3B mediate autocrine
hGH repression of plakoglobin gene transcription and consequent
of mammary carcinoma cells.(Saint-Mix (Synvolux Therapeutics
B.V., The Netherlands)
transfection reagent was used according to the manufacturer’s
Gommans WM, Mol Carcinog. 2007
May;46(5):391-401 Engineering zinc finger protein
transcription factors to downregulate the epithelial
glycoprotein-2 promoter as
a novel anti-cancer treatment. (Transfection of plasmids using
(Synvolux Therapeutics, Groningen, The Netherlands)).
A wide variety of mammalian cells can be transfected with
SAINT-MIX has been used to transfect several cell-types/lines,
some with efficiencies up to 100%.
SAINT-MIX has been demonstrated to act as an efficient
translocator of oligo-nucleotides into eukaryotic cells. The
compatibility with serum is a major advantage of this delivery
system. Oligonucleotide induced cell-damage will be minimal.
SAINT-MIX product description and protocols.
The SAINT-MIX delivery system is based on
a cationic pyridinium head group, showing excellent
bio-compatibility. Molecular structure of SAINT-18
SAINT-MIX consists of SAINT and DOPE
(Dioleoyl-phosphatidylethanolamine) dissolved in H2O. The
SAINT-18: DOPE ratio is 1:1.
Stability experiments showed that
SAINT-MIX, stored at 4°-7°C, is stable for at least one year
after opening. No loss of function appeared after repeatedly
opening of the vials as long as the vials are recapped tightly
after use. The antibiotic properties of SAINT-MIX ensure
sterility for prolonged periods.