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Clonagen

Gentaur

Genprice

Bioxys

Labprice

K101            K102            K103            K104            K105            K106            K121

 

K101 Toxoplasma IgG EIA (semi-quantitative)

Toxoplasmosis is a widespread infection caused by the intracellular protozoan parazite Toxoplasma gondii. In
most of cases, toxoplasmosis is a mild or asymptomatic disease; however, in immunocompromised patients
this disease may be very severe and even life-threatening. Another risk group is pregnant women in whom
primary toxoplasmosis can be transfected to the fetus, causing abortion, and severe malformations.
The non-immune status is revealed by the absence of specific IgG-antibodies in blood serum or plasma.
Specific management of non-immune (specific IgG-negative) pregnant women reduces the risk of
primary infection. Therefore, the determination of specific IgG-antibodies in young women plays an
important role in prophylaxis of damage caused by Toxoplasma gondii.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl
 

 

K102 Rubella IgG EIA (semi-quantitative)

Rubella virus infection in children causes a mild disease with skin rash and enlargement of occipital
lymph nodes, followed by a stable life-long immunity. In adults the infection may exert in more severe
forms with transitory arthritis and in some cases - lethal encephalitis. Rubella infection in pregnant
women may cause serious inborn defects in newborns (cardiac insufficiency, meningoencephalitis,
retinopathy), especially if infection develops during the 1st trimester.
Rubella infection during the 1st trimester of pregnancy is an indication for abortion. Determination of
protective anti-Rubella IgG-antibodies may be used for estimation of immune status in adolescent and
pregnant women.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl

 

K103 CMV IgG EIA (semi-quantitative)

Cytomegalovirus (CMV) belongs to herpesviruses and often causes clinically asymptomatic or mild infection,
mostly in young children . It can be transmitted via stool, saliva, and breast milk. CMV can also be transmitted
via the placenta and cause severe fetal malformations. Specific IgG-antibodies to CMV are evaluated in women
before or during pregnancy to assess and manage the risk of transplacental fetus involvement.
In immunocompromised hosts, CMV reactivation or primary infection may have serious and even lifethreatening
consequences. Therefore, the absence of specific IgG-antibodies to CMV (seronegativity)
in organ transplant recipients requires the seronegativity of the donor.
Specific IgG-antibodies to CMV do not protect from virus reactivation, and usually raise in titer during
reactivation caused by decrease of immune system capacity to control the virus replication.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl
 

 

K104 HSV 1/2 IgG EIA (semi-quantitative)

Herpes simplex virus (HSV) is one of the most common pathogens in humans. HSV is transmitted by all
secretions of infected body, especially via saliva, semen and cervical fluid. Acute HSV infections appear as
a vesicular rash of labial or genital area. In immunocompromised hosts, HSV may cause life-threatening
sequelae in central nervous system. HSV is rarely fully eradicated after acute infections and persists in
human organism lifelong, showing the periodic reactivation. In case of acute infection or reactivation
during pregnancy, HSV may cross the placental barrier and cause severe fetal malformations.
Specific IgG-antibodies to HSV are not protective; their titer usually raise in response to the reactivation
of virus and therefore may be used to monitor the actual status of HSV activity. In pregnant women,
the absence of specific IgG-antibodies (seronegativity) requires tight restrictions of the lifestyle during
the pregnancy minimizing contacts to seropositive humans. The seronegative individuals should not
receive the blood transfusions and organ transplants from seropositive donors.
There are two very similar serotypes of HSV – HSV I and HSV II, showing different distribution in
affected human tissues and organs. The present test system does not detect the differences between
these two serotypes.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl

 

K105 Chlamydia IgG EIA (semi-quantitative)

Chlamydiae are obligate intracellular parasites closely related to Gram negative bacteria. The genus
Chlamydia contains three known species: C.trachomatis, C.psittaci and C.pneumoniae (TWAR) which
share most of their immunoreactive antigens.
C.trachomatis has been recognised as a frequent cause of sexually transmitted diseases, which
may lead to serious malfunction in reproductive function both in men and women (chronic pelvic
inflammation and infertility). This species may also cause conjunctivitis and keratitis in adults and
ophthalmia neonatorum in children born to an infected mother. C.psittaci is transmitted from birds to
humans and causes an atypical pneumonia (ornitosis); C.pneumoniae is the causative agents of both
acute pneumonia and chronic bronchitis. Due to intracellular ‘depot’ of the microorganism, Chlamydia
infections may be asymptomatic and recurrent.
Specific IgG-antibodies to Chlamydia are not protective; their titer usually raise in response to the
reactivation of Chlamydia and therefore may be used to monitor the actual status of infectious activity.
The elevation of these antibodies persist for at least 3-4 weeks after the reactivation, and is not directly
related to antimicrobial therapy. The present test system does not detect the differences between
species of Chlamydia.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl
 

 

K106 Mycoplasma IgG EIA (semi-quantitative)

Mycoplasmae represent a separate class of microorganisms. Unique metabolic properties of Mycoplasmae
determine their poor growth on standard microbiological media and require the application of serological
methods in diagnostics.
Among large variety of species, M.hominis, M.genitalium, M.pneumoniae and closely immunologically
related Ureaplasma urealiticum, play the most considerable role in medical practice. All these
microorganisms share common antigenic epitopes.
M.pneumoniae causes pneumonia, bronchitis and bullous meningitis; other mycoplasmae can cause
acute or chronic pelvic inflammations and may contribute to male and female infertility.
Specific IgG-antibodies to Mycoplasmae do not possess protective properties; however their serum
titer reflects the degree of microbial growth. Therefore, the detection of serum IgG antibodies may be
used for disease and treatment monitoring. Elevated serum IgG antibody titers are detected 3-4 weeks
following the onset of the disease even in case of successful antibiotic treatment.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <4
Sample volume: 100 μl

 

K121 Aspergillus IgG EIA (semi-quantitative)

The fungi of Aspergillus species are important human pathogens and established causative agents of
systemic and local infections as well as allergic diseases. The isotypic pattern of antibody response
to Aspergillus is variable and depends on the form of the disease. Low titre IgG-antibody response
reflects anamnestic infection and has little or no clinical significance. However, in allergic bronchopulmonary
aspergillosis (ABPA) the level of Aspergillus-IgG is significantly elevated and is used as
one of diagnostic criteria of this nosological form. Higher levels of Aspergillus-IgG can be detected in
aspergilloma and invasive aspergillosis. The latter form of aspergillosis is a life-threatening disease
mostly affecting immunosuppressed patients. The elevation of Aspergillus-specific IgG antibody titres in
above mentioned diseases is very dramatic and these antibodies can be detected by immunoprecipitation
(double immunodiffusion, DID).
Our studies showed that in pulmonary diseases, e.g. chronic bronchitis, bronchial asthma, pulmonary
fibrosis etc. the titres of Aspergillus-IgG are significantly elevated, but do not reach the sensitivity
threshold of immunoprecipitation (DID). This milder form of aspergillosis (so called ‘fungal bronchitis’)
is underdiagnosed and the specific anti-fungal treatment is not applicated.
The EIA test for Aspergillus-IgG is designed for the detection of moderately elevated concentrations of
specific antibody to Aspergillus specific antigens.

 

Sample type: serum, plasma                     Incubation: 30’/30’/15’, RT                     Shelf life: 12 months
Sample predilution: 1:21                          Control samples: 3                                Normal range (K value): <5
Sample volume: 100 μl
 

 

 


 


 

 


 

 

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Last modified: 05/29/09