GENTAUR
+32 1658 9045
or
0032 (0)16 41 44 07
+32 1650 9045
[email protected]
Av. de l' Armée 68
B-1040 Brussels
BELGIUM
France
tel 01 43 25 01 50
fax01 43 25 01 60
9, rue Lagrange
75005 Paris
Italia
tel 02 36 00 65 93
fax 02 36 00 65 94
20135 Milano
Deutschland
tel +32 1658 9045
fax +32 1650 9045
Polska
Tel 058 710 33 44
Fax 00 32 16 50 90 45
ul. Grunwaldzka 88A/2
81-771 Sopot
日本
tel +81 78 386 0860
fax +81 78 306 0296
Minaatojimaminami-manchi
Chuo-ku, Kobe
065-0047
Österreich
+43720880899
Canada Montreal
+15149077481
Česká republika Praha
+420246019719
Danmark
+4569918806
Finland Helsset
+358942419041
Ελλάς Αθήνα
+302111768494
Magyarország Budapest
+3619980547
Ireland Dublin
+35316526556
Luxembourg
+35220880274
Nederland
+31208080893
Norge Oslo
+4721031366
Polska Warszawa
+48223988221
Sverige Stockholm
+46852503438
Schweiz Züri
+41435006251
US New York
+17185132983
Other Countries
0032 (0)16 41 44 07
|
|
| |
K101
K102
K103 K104
K105 K106
K121
K101 Toxoplasma
IgG EIA (semi-quantitative)
Toxoplasmosis is a widespread infection caused by the intracellular protozoan
parazite Toxoplasma gondii. In
most of cases, toxoplasmosis is a mild or asymptomatic disease; however, in
immunocompromised patients
this disease may be very severe and even life-threatening. Another risk group is
pregnant women in whom
primary toxoplasmosis can be transfected to the fetus, causing abortion, and
severe malformations.
The non-immune status is revealed by the absence of specific IgG-antibodies in
blood serum or plasma.
Specific management of non-immune (specific IgG-negative) pregnant women reduces
the risk of
primary infection. Therefore, the determination of specific IgG-antibodies in
young women plays an
important role in prophylaxis of damage caused by Toxoplasma gondii.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
K102 Rubella
IgG EIA (semi-quantitative)
Rubella virus infection in children causes a mild disease with skin rash and
enlargement of occipital
lymph nodes, followed by a stable life-long immunity. In adults the infection
may exert in more severe
forms with transitory arthritis and in some cases - lethal encephalitis. Rubella
infection in pregnant
women may cause serious inborn defects in newborns (cardiac insufficiency,
meningoencephalitis,
retinopathy), especially if infection develops during the 1st trimester.
Rubella infection during the 1st trimester of pregnancy is an indication for
abortion. Determination of
protective anti-Rubella IgG-antibodies may be used for estimation of immune
status in adolescent and
pregnant women.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
K103 CMV IgG
EIA (semi-quantitative)
Cytomegalovirus (CMV) belongs to herpesviruses and often causes clinically
asymptomatic or mild infection,
mostly in young children . It can be transmitted via stool, saliva, and breast
milk. CMV can also be transmitted
via the placenta and cause severe fetal malformations. Specific IgG-antibodies
to CMV are evaluated in women
before or during pregnancy to assess and manage the risk of transplacental fetus
involvement.
In immunocompromised hosts, CMV reactivation or primary infection may have
serious and even lifethreatening
consequences. Therefore, the absence of specific IgG-antibodies to CMV
(seronegativity)
in organ transplant recipients requires the seronegativity of the donor.
Specific IgG-antibodies to CMV do not protect from virus reactivation, and
usually raise in titer during
reactivation caused by decrease of immune system capacity to control the virus
replication.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
K104 HSV 1/2
IgG EIA (semi-quantitative)
Herpes simplex virus (HSV) is one of the most common pathogens in humans. HSV is
transmitted by all
secretions of infected body, especially via saliva, semen and cervical fluid.
Acute HSV infections appear as
a vesicular rash of labial or genital area. In immunocompromised hosts, HSV may
cause life-threatening
sequelae in central nervous system. HSV is rarely fully eradicated after acute
infections and persists in
human organism lifelong, showing the periodic reactivation. In case of acute
infection or reactivation
during pregnancy, HSV may cross the placental barrier and cause severe fetal
malformations.
Specific IgG-antibodies to HSV are not protective; their titer usually raise in
response to the reactivation
of virus and therefore may be used to monitor the actual status of HSV activity.
In pregnant women,
the absence of specific IgG-antibodies (seronegativity) requires tight
restrictions of the lifestyle during
the pregnancy minimizing contacts to seropositive humans. The seronegative
individuals should not
receive the blood transfusions and organ transplants from seropositive donors.
There are two very similar serotypes of HSV – HSV I and HSV II, showing
different distribution in
affected human tissues and organs. The present test system does not detect the
differences between
these two serotypes.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
K105 Chlamydia
IgG EIA (semi-quantitative)
Chlamydiae are obligate intracellular parasites closely related to Gram negative
bacteria. The genus
Chlamydia contains three known species: C.trachomatis, C.psittaci and
C.pneumoniae (TWAR) which
share most of their immunoreactive antigens.
C.trachomatis has been recognised as a frequent cause of sexually transmitted
diseases, which
may lead to serious malfunction in reproductive function both in men and women
(chronic pelvic
inflammation and infertility). This species may also cause conjunctivitis and
keratitis in adults and
ophthalmia neonatorum in children born to an infected mother. C.psittaci is
transmitted from birds to
humans and causes an atypical pneumonia (ornitosis); C.pneumoniae is the
causative agents of both
acute pneumonia and chronic bronchitis. Due to intracellular ‘depot’ of the
microorganism, Chlamydia
infections may be asymptomatic and recurrent.
Specific IgG-antibodies to Chlamydia are not protective; their titer usually
raise in response to the
reactivation of Chlamydia and therefore may be used to monitor the actual status
of infectious activity.
The elevation of these antibodies persist for at least 3-4 weeks after the
reactivation, and is not directly
related to antimicrobial therapy. The present test system does not detect the
differences between
species of Chlamydia.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
K106 Mycoplasma
IgG EIA (semi-quantitative)
Mycoplasmae represent a separate class of microorganisms. Unique metabolic
properties of Mycoplasmae
determine their poor growth on standard microbiological media and require the
application of serological
methods in diagnostics.
Among large variety of species, M.hominis, M.genitalium, M.pneumoniae and
closely immunologically
related Ureaplasma urealiticum, play the most considerable role in medical
practice. All these
microorganisms share common antigenic epitopes.
M.pneumoniae causes pneumonia, bronchitis and bullous meningitis; other
mycoplasmae can cause
acute or chronic pelvic inflammations and may contribute to male and female
infertility.
Specific IgG-antibodies to Mycoplasmae do not possess protective properties;
however their serum
titer reflects the degree of microbial growth. Therefore, the detection of serum
IgG antibodies may be
used for disease and treatment monitoring. Elevated serum IgG antibody titers
are detected 3-4 weeks
following the onset of the disease even in case of successful antibiotic
treatment.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <4
Sample volume: 100 μl
K121
Aspergillus IgG EIA (semi-quantitative)
The fungi of Aspergillus species are important human pathogens and established
causative agents of
systemic and local infections as well as allergic diseases. The isotypic pattern
of antibody response
to Aspergillus is variable and depends on the form of the disease. Low titre
IgG-antibody response
reflects anamnestic infection and has little or no clinical significance.
However, in allergic bronchopulmonary
aspergillosis (ABPA) the level of Aspergillus-IgG is significantly elevated and
is used as
one of diagnostic criteria of this nosological form. Higher levels of
Aspergillus-IgG can be detected in
aspergilloma and invasive aspergillosis. The latter form of aspergillosis is a
life-threatening disease
mostly affecting immunosuppressed patients. The elevation of
Aspergillus-specific IgG antibody titres in
above mentioned diseases is very dramatic and these antibodies can be detected
by immunoprecipitation
(double immunodiffusion, DID).
Our studies showed that in pulmonary diseases, e.g. chronic bronchitis,
bronchial asthma, pulmonary
fibrosis etc. the titres of Aspergillus-IgG are significantly elevated, but do
not reach the sensitivity
threshold of immunoprecipitation (DID). This milder form of aspergillosis (so
called ‘fungal bronchitis’)
is underdiagnosed and the specific anti-fungal treatment is not applicated.
The EIA test for Aspergillus-IgG is designed for the detection of moderately
elevated concentrations of
specific antibody to Aspergillus specific antigens.
Sample type: serum, plasma
Incubation: 30’/30’/15’, RT
Shelf life: 12 months
Sample predilution: 1:21
Control samples: 3
Normal range (K value): <5
Sample volume: 100 μl
|