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Hormones in saliva and other Hormones

 

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Clonagen

Gentaur

Genprice

Bioxys

Labprice

K204            K210            K209S            K210S

 

K204 Human Growth (Somatotropic) Hormone EIA

Human growth hormone (GH) is a monomeric protein with molecular weight of 21.5 kDa which is secreted
by hypophysis. GH stimulates growth and possesses anabolic activity. GH takes part in regulation
of various metabolic processes but its main activity is directed towards regulation of protein metabolism
and growth.
Normally, secretion of GH is not even – it occurs as 5-10 discharges a day giving peak levels. Between
these peaks, concentration of GH in blood may be rather low. Due to this, estimation of GH level in blood
for diagnostics of acromegaly or gigantism is recommended to be done at fasting serially, during
2-3 days, with calculation of average value. If GH levels are near normal range, serial determination
during a day is necessary to confirm diagnosis and to determine a stage of a disease.
Elevation of GH concentration in blood is found in acromegaly and gigantism, after starvation , in stress
conditions and alcoholic states, in chronic renal insufficiency, hyperglycemia, hyperpituitarism, after
physical stress.
Decreased blood levels of GH are seen in dwarfism due to hypophysis insufficiency (circadian
rhythms of GH secretion are also absent in this condition), hypercorticism, Cushing syndrome,
hypopituitarism.

 

Sample type: serum, plasma                         Incubation: 60’/60’/15’, RT,                         Control sample: 1
Sample volume: 50 μl                                                    shaker                                    Shelf life: 12 months
Sensitivity: 0.25 mIU/l                                 Calibrators: 5 (0-50 mIU/l)

 

K210 Cortisol EIA

Cortisol is a glucocorticoid with a MW of 362.5 Dalton. Cortisol is the major hormone secreted by adrenals.
In blood, cortisol is found mostly in a bound form, transcortin being the carrier. Cortisol secretion
undergoes circadian rhythms with maximal (up to 700 nmol/l) concentrations seen in the morning
(6-9 am) and minimal (up to 55 nmol/l) – in the midnight.
During pregnancy, Cortisol blood level is continuously increasing by up to 5-fold of initial concentration
before delivery, its circadian rhythm being altered. Cortisol plays an important role in development
of alveolar epithelium and surfactant secretion, this being of major importance for the first inhale
of a newborn.
Elevated Cortisol concentrations in blood are found in secreting tumors of adrenals, in virilizing
hyperplasia of adrenals, in Cushing syndrome, in ACTH-producing tumors, during surgical stress,
in cardiac insufficiency, diabetes, burns, pains, during pregnancy, during estrogen therapy, etc. Cortisol
blood level may be increased by intake of ACTH, Cortisol, alcohol, nicotine, oral contraceptives.
Decreased Cortisol levels are found in Addison syndrome, adrenogenital syndrome, hypopituitarism.
Some drugs may decrease Cortisol level in blood, such as: L-DOPA, dexamethasone, etc. Decreased
Cortisol level during pregnancy may indicate anencephaly of the fetus.
 

 

Sample type: serum, plasma                         Incubation: 60’/15’, 370С                           Control sample: 1
Sample volume: 25 μl                                   Calibrators: 6 (0-1000 nmol/l)                    Shelf life: 12 months
Sensitivity: 25 nmol/l

 

K209S Salivary Testosterone EIA                                                                               New kit!

In serum, Testosterone is found both in free and bound form, the latter being a complex with transport
proteins (SHBG, albumin). But only free form exerts biological activity, although its proportion is lt 1%
of total Testosterone. Currently, there are no reliable immunochemical method for quantitative
determination of free Testosterone in serum. At the same time, complicated reference laboratory
methods (e.g., dialysis) are not suitable for everyday use. That is why the only method of direct
determination of free Testosterone is its determination in saliva. Follow-up of salivary Testosterone
level is a very informative and non-traumatic method widely used in endocrinology, physiology,
sport medicine, veterinary, etc. for estimation of masculine status. Elevated salivary Testosterone
in females is characteristic for hirsutism, polycystosis of ovaries and serves as a laboratory marker
of masculinization. Stably low levels of salivary Testosterone in males suggest primary or secondary
hypogonadism.

 

Sample type: saliva                                     Incubation: 120’/15’, 370С                          Control sample: 1
Sample volume: 100 μl                                 Calibrators: 7 (0-10 ng/ml)                         Shelf life: 12 months
Sensitivity: 0.015 ng/ml
 

 

K210S Salivary Cortisol EIA                                                                                      New kit!

In serum, Cortisol is found both in free and bound form, the latter being a complex with transport
proteins (transcortin, albumin). But only free form exerts biological activity, its proportion being
ca. 10% of total Cortisol. Currently, there are no reliable immunochemical method for quantitative
determination of free Cortisol in serum. At the same time, complicated reference laboratory methods
(e.g., dialysis) are not suitable for everyday use. That is why the only method of direct determination
of free Cortisol is its determination in saliva. Follow-up of salivary Cortisol level is a very informative
and non-traumatic method widely used in endocrinology, physiology, sport medicine, veterinary,
etc. for estimation of adrenal glands function, differential diagnostics of Cushing syndrome with its
characteristic alteration of circadian rhythm of Cortisol secretion being a good example.

 

Sample type: saliva                                     Incubation: 90’/15’, 370С                            Control sample: 1
Sample volume: 50 μl                                   Calibrators: 6 (0-38.4 ng/ml)                       Shelf life: 12 months
Sensitivity: 0.07 ng/ml
 

 

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Last modified: 05/29/09